Inhibition of soluble epoxide hydrolase improves the impaired pressure–natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats

OBJECTIVE: In the present study, we compared the effects of treatment with the novel soluble epoxide hydrolase (sEH) inhibitor (c-AUCB) with those of the AT(1) receptor antagonist losartan on blood pressure (BP), autoregulation of renal blood flow (RBF) and on glomerular filtration rate (GFR) and th...

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Auteurs principaux: Honetschlägerová, Zuzana, Sporková, Alexandra, Kopkan, Libor, Husková, Zuzana, Hwang, Sung H., Hammock, Bruce D., Imig, John D., Kramer, Herbert J., Kujal, Petr, Vernerová, Zdenka, Chábová, Věra Č., Tesař, Vladimír, Červenka, Luděk
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777565/
https://ncbi.nlm.nih.gov/pubmed/21720266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HJH.0b013e328349062f
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