Soluble epoxide hydrolase inhibition exhibits antihypertensive actions independently of nitric oxide in mice with renovascular hypertension

OBJECTIVE: The present study was performed to examine whether the blood pressure (BP)-lowering effects of soluble epoxide hydrolase (sEH) inhibition in two-kidney, one-clip (2K1C) Goldblatt hypertension are nitric oxide (NO)-dependent. METHODS: Mice lacking the endothelial NO synthase (eNOS) gene (e...

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Detalhes bibliográficos
Main Authors: Kopkan, Libor, Husková, Zuzana, Sporková, Alexandra, Varcabová, Šárka, Honetschlägerová, Zuzana, Hwang, Sung Hee, Tsai, Hsing-Ju, Hammock, Bruce D., Imig, John D., Kramer, Herbert J., Bürgelová, Marcela, Vojtíšková, Alžběta, Kujal, Petr, Vernerová, Zdenka, Červenka, Luděk
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3604982/
https://ncbi.nlm.nih.gov/pubmed/22948718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000339883
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