Structure activity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function

17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido)morphinan (NAQ) was previously designed following the “message–address” concept and was identified as a potent and highly selective mu opioid receptor (MOR) ligand based on its pharmacological profile. We here report the...

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Detaylı Bibliyografya
Asıl Yazarlar: Yuan, Yunyun, Elbegdorj, Orgil, Beletskaya, Irina O., Selley, Dana E., Zhang, Yan
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776595/
https://ncbi.nlm.nih.gov/pubmed/23948248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.043
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