TGF-β downregulates PTEN via activation of NF-κB in pancreatic cancer cells

TGF-β utilizes receptor-activated SMAD signaling to mediate growth suppression; however, non-SMAD signaling that modulates the TGF-β response in epithelial cells become apparent when the SMAD signaling is abrogated, a common occurrence in pancreatic cancers. Here, we examined whether TGF-β utilized...

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Autors principals: Chow, Jimmy Y. C., Ban, Makiko, Wu, Helen L., Nguyen, Flang, Huang, Mei, Chung, Heekyung, Dong, Hui, Carethers, John M.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
Matèries:
Hormones and Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774494/
https://ncbi.nlm.nih.gov/pubmed/19940030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00344.2009
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