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Downregulation of STAT3/NF-κB potentiates gemcitabine activity in pancreatic cancer cells

There is an unmet need to develop new agents or strategies against therapy resistant pancreatic cancer (PanCA). Recent studies from our laboratory showed that STAT3 negatively regulates NF-κB and that inhibition of this crosstalk using Nexrutine(®) (Nx) reduces transcriptional activity of COX-2. Inh...

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Detalhes bibliográficos
Publicado no:Mol Carcinog
Main Authors: Gong, Jingjing, Muñoz, Amanda R, Pingali, Subramanya, Payton-Stewart, Florastina, Chan, Daniel E, Freeman, James W, Ghosh, Rita, Kumar, Addanki P
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5800424/
https://ncbi.nlm.nih.gov/pubmed/27208550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22503
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