CYP-epoxygenases contribute to A(2A) receptor-mediated aortic relaxation via sarcolemmal K(ATP) channels

Previously, we have shown that A(2A) adenosine receptor (A(2A)AR) mediates aortic relaxation via cytochrome P-450 (CYP)-epoxygenases. However, the signaling mechanism is not understood properly. We hypothesized that ATP-sensitive K(+) (K(ATP)) channels play an important role in A(2A)AR-mediated rela...

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Bibliographic Details
Main Authors: Ponnoth, Dovenia S., Nayeem, Mohammed A., Tilley, Stephen L., Ledent, Catherine, Jamal Mustafa, S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Cardiovascular and Renal Integration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774479/
https://ncbi.nlm.nih.gov/pubmed/23019210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00335.2012
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