Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload

Expression of GSK-3α is increased in aging hearts and those subjected to hemodynamic overload. Overexpressed GSK-3α inhibits ERK and enhances pressure overload (PO)-induced cardiac dysfunction. We studied whether suppression of the MEK1/ERK pathway contributes to cardiac responses induced by overexp...

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Hlavní autoři: Maejima, Yasuhiro, Galeotti, Jonathan, Molkentin, Jeffery D., Sadoshima, Junichi, Zhai, Peiyong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Signaling and Stress Response
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774208/
https://ncbi.nlm.nih.gov/pubmed/22904158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00415.2012
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