Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases

BACKGROUND: Arginine-specific (RgpB and RgpA) and lysine-specific (Kgp) gingipains are secretory cysteine proteinases of Porphyromonas gingivalis that act as important virulence factors for the organism. They are translated as zymogens with both N- and C-terminal extensions, which are proteolyticall...

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書誌詳細
主要な著者: Veillard, Florian, Sztukowska, Maryta, Mizgalska, Danuta, Ksiazek, Mirosław, Houston, John, Potempa, Barbara, Enghild, Jan J., Thogersen, Ida B., Gomis-Rüth, F. Xavier, Nguyen, Ky-Anh, Potempa, Jan
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773880/
https://ncbi.nlm.nih.gov/pubmed/23583629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2013.04.005
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