Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whether antiviral function can be restored in infected i...

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Detalhes bibliográficos
Main Authors: Fuller, Michael J., Callendret, Benoit, Zhu, Baogong, Freeman, Gordon J., Hasselschwert, Dana L., Satterfield, William, Sharpe, Arlene H., Dustin, Lynn B., Rice, Charles M., Grakoui, Arash, Ahmed, Rafi, Walker, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773803/
https://ncbi.nlm.nih.gov/pubmed/23980172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312772110
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