Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

Hepatitis C virus (HCV) persistence is facilitated by exhaustion of CD8+ T cells that express the inhibitory receptor programmed cell death 1 (PD-1). Blockade of PD-1 signaling improves in vitro proliferation of HCV-specific T lymphocytes, but whether antiviral function can be restored in infected i...

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Main Authors: Fuller, Michael J., Callendret, Benoit, Zhu, Baogong, Freeman, Gordon J., Hasselschwert, Dana L., Satterfield, William, Sharpe, Arlene H., Dustin, Lynn B., Rice, Charles M., Grakoui, Arash, Ahmed, Rafi, Walker, Christopher M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3773803/
https://ncbi.nlm.nih.gov/pubmed/23980172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312772110
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