Destabilization of the Epidermal Growth Factor Receptor (EGFR) by a Peptide That Inhibits EGFR Binding to Heat Shock Protein 90 and Receptor Dimerization

An eight-amino acid segment is known to be responsible for the marked difference in the rates of degradation of the EGF receptor (ErbB1) and ErbB2 upon treatment of cells with the Hsp90 inhibitor geldanamycin. We have scrambled the first six amino acids of this segment of the EGF receptor (EGFR), wh...

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Main Authors: Ahsan, Aarif, Ray, Dipankar, Ramanand, Susmita G., Hegde, Ashok, Whitehead, Christopher, Rehemtulla, Alnawaz, Morishima, Yoshihiro, Pratt, William B., Osawa, Yoichi, Lawrence, Theodore S., Nyati, Mukesh K.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2013
נושאים:
Protein Synthesis and Degradation
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3772236/
https://ncbi.nlm.nih.gov/pubmed/23897823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.492280
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