Wild-type EGFR Is Stabilized by Direct Interaction with HSP90 in Cancer Cells and Tumors

The epidermal growth factor receptor (EGFR) has been targeted for inhibition using tyrosine kinase inhibitors and monoclonal antibodies, with improvement in outcome in subsets of patients with head and neck, lung, and colorectal carcinomas. We have previously found that EGFR stability plays a key ro...

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Main Authors: Ahsan, Aarif, Ramanand, Susmita G, Whitehead, Christopher, Hiniker, Susan M, Rehemtulla, Alnawaz, Pratt, William B, Jolly, Shruti, Gouveia, Christopher, Truong, Kristy, Van Waes, Carter, Ray, Dipankar, Lawrence, Theodore S, Nyati, Mukesh K
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431175/
https://ncbi.nlm.nih.gov/pubmed/22952420
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