Efficacy of an EGFR-Specific Peptide against EGFR-Dependent Cancer Cell Lines and Tumor Xenografts

We have recently synthesized a peptide called Disruptin, which comprised the SVDNPHVC segment of the epidermal growth factor receptor (EGFR) that inhibits binding of heat shock protein 90 (Hsp90) to the EGFR and EGF-dependent EGFR dimerization to cause EGFR degradation. The effect is specific for EG...

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Hlavní autoři: Ahsan, Aarif, Ramanand, Susmita G, Bergin, Ingrid L, Zhao, Lilli, Whitehead, Christopher E, Rehemtulla, Alnawaz, Ray, Dipankar, Pratt, William B, Lawrence, Theodore S, Nyati, Mukesh K
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978391/
https://ncbi.nlm.nih.gov/pubmed/24709418
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