Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission

Proper completion of mitosis requires the concerted effort of multiple RhoGEFs. Here we show that leukemia-associated RhoGEF (LARG), a RhoA-specific RGS-RhoGEF, is required for abscission, the final stage of cytokinesis, in which the intercellular membrane is cleaved between daughter cells. LARG col...

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Autori principali: Martz, Matthew K., Grabocka, Elda, Beeharry, Neil, Yen, Timothy J., Wedegaertner, Philip B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771942/
https://ncbi.nlm.nih.gov/pubmed/23885121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E12-07-0533
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