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Functional consequences of Gα(13) mutations that disrupt interaction with p115RhoGEF

The G-protein α subunit, α(13), regulates cell growth and differentiation through the monomeric Rho GTPase. α(13) activates Rho through direct stimulation of the guanine nucleotide exchange factor p115RhoGEF, which contains a regulator of G-protein signaling homology domain (RH) in its N-terminus. T...

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Main Authors: Grabocka, Elda, Wedegaertner, Philip B.
格式: Artigo
語言:Inglês
出版: 2005
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1351220/
https://ncbi.nlm.nih.gov/pubmed/15735747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1208414
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