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K(ATP) channel Kir6.2 E23K variant overrepresented in human heart failure is associated with impaired exercise stress response

ATP-sensitive K(+) (K(ATP)) channels maintain cardiac homeostasis under stress, as revealed by murine gene knockout models of the KCNJ11-encoded Kir6.2 pore. However, the translational significance of K(ATP) channels in human cardiac physiology remains largely unknown. Here, the frequency of the min...

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Bibliographic Details
Main Authors: Reyes, Santiago, Park, Sungjo, Johnson, Bruce D., Terzic, Andre, Olson, Timothy M.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3771654/
https://ncbi.nlm.nih.gov/pubmed/19685080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00439-009-0731-9
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