SPAK Deficiency Corrects Pseudohypoaldosteronism II Caused by WNK4 Mutation

Stimulation of the OSR1 (Oxidative stress-responsive kinase-1)/SPAK [STE20 (sterile 20)/SPS1-related proline/alanine-rich kinase]-NCC (Na(+)-Cl(−) cotransporter) signaling cascade plays an important role in the WNK [With-No-Lysine (K)] kinase 4 D561A knock-in mouse model of pseudohypoaldosteronism t...

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Detalles Bibliográficos
Autores principales: Chu, Pei-Yi, Cheng, Chih-Jen, Wu, Yi-Chang, Fang, Yu-Wei, Chau, Tom, Uchida, Shinichi, Sasaki, Sei, Yang, Sung-Sen, Lin, Shih-Hua
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770638/
https://ncbi.nlm.nih.gov/pubmed/24039833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0072969
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