Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway

The mechanism by which chronic metabolic acidosis (CMA) regulates sodium (Na(+))-chloride (Cl(−)) cotransporter (NCC) in the renal distal convoluted tubules remains unexplored. We examined the role of STE20/SPS1-related proline/alanine-rich kinase (SPAK) and with-no-lysine kinase 4 (WNK4) on express...

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Publicado en:Sci Rep
Main Authors: Fang, Yu-Wei, Yang, Sung-Sen, Cheng, Chih-Jen, Tseng, Min-Hua, Hsu, Hui-Min, Lin, Shih-Hua
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4700450/
https://ncbi.nlm.nih.gov/pubmed/26728390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18360
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