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DNA Topoisomerases Participate in Fragility of the Oncogene RET

Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under conditions that partially inhibit DNA replication...

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Détails bibliographiques
Auteurs principaux: Dillon, Laura W., Pierce, Levi C. T., Lehman, Christine E., Nikiforov, Yuri E., Wang, Yuh-Hwa
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770543/
https://ncbi.nlm.nih.gov/pubmed/24040417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075741
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