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DNA fragile site breakage as a measure of chemical exposure and predictor of individual susceptibility to form oncogenic rearrangements

Chromosomal rearrangements induced by non-radiation causes contribution to the majority of oncogenic fusions found in cancer. Treatment of human thyroid cells with fragile site-inducing laboratory chemicals can cause preferential DNA breakage at the RET gene and generate the RET/PTC1 rearrangement,...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Carcinogenesis
Päätekijät: Lehman, Christine E., Dillon, Laura W., Nikiforov, Yuri E., Wang, Yuh-Hwa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862292/
https://ncbi.nlm.nih.gov/pubmed/28069693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgw210
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