BimEL is phosphorylated at mitosis by Aurora A and targeted for degradation by βTrCP1

Bcl-2-interacting mediator of cell death (Bim) is a pro-apoptotic B-cell lymphoma 2 family member implicated in numerous apoptotic stimuli. In particular, Bim is required for cell death mediated by antimitotic agents, however, mitotic regulation of Bim remains poorly understood. Here, we show that t...

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Sonraí Bibleagrafaíochta
Main Authors: Moustafa-Kamal, M, Gamache, I, Lu, Y, Li, S, Teodoro, J G
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2013
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Original Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3770328/
https://ncbi.nlm.nih.gov/pubmed/23912711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.93
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