Local proliferation dominates lesional macrophage accumulation in atherosclerosis

During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall(1,2). The observation that circulating monocytes give rise to lesional macrophages(3–9) has reinforced the concept that monocyte infiltration dictates macrophage build-up....

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Autores principales: Robbins, Clinton S., Hilgendorf, Ingo, Weber, Georg F., Theurl, Igor, Iwamoto, Yoshiko, Figueiredo, Jose-Luiz, Gorbatov, Rostic, Sukhova, Galina K., Gerhardt, Louisa M.S., Smyth, David, Zavitz, Caleb C. J., Shikatani, Eric A., Parsons, Michael, van Rooijen, Nico, Lin, Herbert Y., Husain, Mansoor, Libby, Peter, Nahrendorf, Matthias, Weissleder, Ralph, Swirski, Filip K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769444/
https://ncbi.nlm.nih.gov/pubmed/23933982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3258
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