Local proliferation dominates lesional macrophage accumulation in atherosclerosis

During the inflammatory response that drives atherogenesis, macrophages accumulate progressively in the expanding arterial wall(1,2). The observation that circulating monocytes give rise to lesional macrophages(3–9) has reinforced the concept that monocyte infiltration dictates macrophage build-up....

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Main Authors: Robbins, Clinton S., Hilgendorf, Ingo, Weber, Georg F., Theurl, Igor, Iwamoto, Yoshiko, Figueiredo, Jose-Luiz, Gorbatov, Rostic, Sukhova, Galina K., Gerhardt, Louisa M.S., Smyth, David, Zavitz, Caleb C. J., Shikatani, Eric A., Parsons, Michael, van Rooijen, Nico, Lin, Herbert Y., Husain, Mansoor, Libby, Peter, Nahrendorf, Matthias, Weissleder, Ralph, Swirski, Filip K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3769444/
https://ncbi.nlm.nih.gov/pubmed/23933982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3258
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