HLA-C–Dependent Prevention of Leukemia Relapse by Donor Activating KIR2DS1

BACKGROUND: Of the cancers treated with allogeneic hematopoietic stem-cell transplantation (HSCT), acute myeloid leukemia (AML) is most sensitive to natural killer (NK)–cell reactivity. The activating killer-cell immunoglobulin-like receptor (KIR) 2DS1 has ligand specificity for HLA-C2 antigens and...

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Detalhes bibliográficos
Main Authors: Venstrom, Jeffrey M., Pittari, Gianfranco, Gooley, Ted A., Chewning, Joseph H., Spellman, Stephen, Haagenson, Michael, Gallagher, Meighan M., Malkki, Mari, Petersdorf, Effie, Dupont, Bo, Hsu, Katharine C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767478/
https://ncbi.nlm.nih.gov/pubmed/22931314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1200503
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