The oncogenic microRNA miR-22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation

MicroRNAs are frequently deregulated in cancer. Here we show that miR-22 is upregulated in myelodysplastic syndrome (MDS) and leukemia, and its aberrant expression correlates with poor survival. To explore its role in hematopoietic stem cell function and malignancy, we generated transgenic mice cond...

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Autors principals: Song, Su Jung, Ito, Keisuke, Ala, Ugo, Kats, Lev, Webster, Kaitlyn, Sun, Suming, Manova-Todorova, Katia, Teruya-Feldstein, Julie, Avigan, David E., Delwel, Ruud, Pandolfi, Pier Paolo
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767186/
https://ncbi.nlm.nih.gov/pubmed/23827711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2013.06.003
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