microRNA-antagonism regulates breast cancer stemness and metastasis via TET family dependent chromatin remodeling

Tumor cells metastasize to distant organs through genetic and epigenetic alterations, including changes in microRNA (miR) expression. Here we find miR-22 triggers epithelial-mesenchymal transition (EMT), enhances invasiveness and promotes metastasis in mouse xenografts. In a conditional mammary glan...

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Detalhes bibliográficos
Main Authors: Song, Su Jung, Poliseno, Laura, Song, Min Sup, Ala, Ugo, Webster, Kaitlyn, Ng, Christopher, Beringer, Gary, Brikbak, Nicolai J., Yuan, Xin, Cantley, Lewis C., Richardson, Andrea L., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767157/
https://ncbi.nlm.nih.gov/pubmed/23830207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.06.026
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