Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Here we demonstrate that protein-coding RNA transcripts can crosstalk by competing for common microRNAs, with microRNA response elements as the foundation of this interaction. We have termed such RNA transcripts as competing endogenous RNAs (ceRNAs). We tested this hypothesis in the context of PTEN,...

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Main Authors: Tay, Yvonne, Kats, Lev, Salmena, Leonardo, Weiss, Dror, Tan, Shen Mynn, Ala, Ugo, Karreth, Florian, Poliseno, Laura, Provero, Paolo, Di Cunto, Ferdinando, Lieberman, Judy, Rigoutsos, Isidore, Pandolfi, Pier Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235920/
https://ncbi.nlm.nih.gov/pubmed/22000013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.029
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