Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Here we demonstrate that protein-coding RNA transcripts can crosstalk by competing for common microRNAs, with microRNA response elements as the foundation of this interaction. We have termed such RNA transcripts as competing endogenous RNAs (ceRNAs). We tested this hypothesis in the context of PTEN,...

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Detalhes bibliográficos
Main Authors: Tay, Yvonne, Kats, Lev, Salmena, Leonardo, Weiss, Dror, Tan, Shen Mynn, Ala, Ugo, Karreth, Florian, Poliseno, Laura, Provero, Paolo, Di Cunto, Ferdinando, Lieberman, Judy, Rigoutsos, Isidore, Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235920/
https://ncbi.nlm.nih.gov/pubmed/22000013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.09.029
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