A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin

A novel acetylenic tricyclic bis-(cyano enone), TBE-31, is a lead compound in a series of tricyclic compounds with enone functionalities in rings A and C. Nanomolar concentrations of this potent multifunctional molecule suppress the induction of the inflammatory protein, iNOS; activate phase 2 cytop...

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Main Authors: Liby, Karen, Yore, Mark M., Roebuck, Bill D., Baumgartner, Karen J., Honda, Tadashi, Sundararajan, Chitra, Yoshizawa, Hidenori, Gribble, Gordon W., Williams, Charlotte R., Risingsong, Renee, Royce, Darlene B., Dinkova-Kostova, Albena T., Stephenson, Katherine K., Egner, Patricia A., Yates, Melinda S., Groopman, John D., Kensler, Thomas W., Sporn, Michael B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3767150/
https://ncbi.nlm.nih.gov/pubmed/18701497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-1123
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