The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling

The plasma membrane and all membrane-bound organelles except for the Golgi and endoplasmic reticulum (ER) are equipped with pattern-recognition molecules to sense microbes or their products and induce innate immunity for host defense. Here, we report that inositol-requiring-1α (IRE1α), an ER protein...

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Detalhes bibliográficos
Main Authors: Cho, Jin A., Lee, Ann-Hwee, Platzer, Barbara, Cross, Benedict C.S., Gardner, Brooke M., De Luca, Heidi, Luong, Phi, Harding, Heather P., Glimcher, Laurie H., Walter, Peter, Fiebiger, Edda, Ron, David, Kagan, Jonathan C., Lencer, Wayne I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3766372/
https://ncbi.nlm.nih.gov/pubmed/23684307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.03.011
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