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Unfolded Proteins are Ire1-Activating Ligands that Directly Induce the Unfolded Protein Response
The unfolded protein response (UPR) detects the accumulation of unfolded proteins in the endoplasmic reticulum (ER) and adjusts the protein folding capacity to the needs of the cell. Under conditions of ER stress, the transmembrane protein Ire1 oligomerizes to activate its cytoplasmic kinase and RNa...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3202989/ https://ncbi.nlm.nih.gov/pubmed/21852455 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1209126 |
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