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The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold
BACKGROUND: Drugs targeting insomnia ideally promote sleep throughout the night, maintain normal sleep architecture, and are devoid of residual effects associated with morning sedation. These features of an ideal compound are not only dependent upon pharmacokinetics, receptor binding kinetics, poten...
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| Asıl Yazarlar: | , , , , , , , , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
BioMed Central
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3765993/ https://ncbi.nlm.nih.gov/pubmed/23981345 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-14-90 |
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