Design and pharmacological characterization of VUF14480, a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H(4) receptor

BACKGROUND AND PURPOSE: The recently proposed binding mode of 2-aminopyrimidines to the human (h) histamine H(4) receptor suggests that the 2-amino group of these ligands interacts with glutamic acid residue E182(5.46) in the transmembrane (TM) helix 5 of this receptor. Interestingly, substituents a...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Nijmeijer, S, Engelhardt, H, Schultes, S, van de Stolpe, A C, Lusink, V, de Graaf, C, Wijtmans, M, Haaksma, E E J, de Esch, I J P, Stachurski, K, Vischer, H F, Leurs, R
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Themed Issue: Histamine Pharmacology Update
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764852/
https://ncbi.nlm.nih.gov/pubmed/23347159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12113
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados