Detailed analysis of biased histamine H(4) receptor signalling by JNJ 7777120 analogues

BACKGROUND AND PURPOSE: The histamine H(4) receptor, originally thought to signal merely through Gα(i) proteins, has recently been shown to also recruit and signal via β-arrestin2. Following the discovery that the reference antagonist indolecarboxamide JNJ 7777120 appears to be a partial agonist in...

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Autori principali: Nijmeijer, S, Vischer, H F, Sirci, F, Schultes, S, Engelhardt, H, de Graaf, C, Rosethorne, E M, Charlton, S J, Leurs, R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Themed Issue: Histamine Pharmacology Update
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764851/
https://ncbi.nlm.nih.gov/pubmed/23351115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12117
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