β-Glucosidase 2 (GBA2) Activity and Imino Sugar Pharmacology

β-Glucosidase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide into glucose and ceramide. The GBA2 gene is mutated in genetic neurological diseases (hereditary spastic paraplegia and cerebellar ataxia). Pharmacologically, GBA2 is reversibly inhibited by alkylated imino sugars t...

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Bibliografski detalji
Glavni autori: Ridley, Christina M., Thur, Karen E., Shanahan, Jessica, Thillaiappan, Nagendra Babu, Shen, Ann, Uhl, Karly, Walden, Charlotte M., Rahim, Ahad A., Waddington, Simon N., Platt, Frances M., van der Spoel, Aarnoud C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Lipids
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764809/
https://ncbi.nlm.nih.gov/pubmed/23880767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463562
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