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β-Glucosidase 2 (GBA2) Activity and Imino Sugar Pharmacology

β-Glucosidase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide into glucose and ceramide. The GBA2 gene is mutated in genetic neurological diseases (hereditary spastic paraplegia and cerebellar ataxia). Pharmacologically, GBA2 is reversibly inhibited by alkylated imino sugars t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ridley, Christina M., Thur, Karen E., Shanahan, Jessica, Thillaiappan, Nagendra Babu, Shen, Ann, Uhl, Karly, Walden, Charlotte M., Rahim, Ahad A., Waddington, Simon N., Platt, Frances M., van der Spoel, Aarnoud C.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764809/
https://ncbi.nlm.nih.gov/pubmed/23880767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463562
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