Accumulation of Glucosylceramide in the Absence of the Beta-Glucosidase GBA2 Alters Cytoskeletal Dynamics

Glycosphingolipids are key elements of cellular membranes, thereby, controlling a variety of cellular functions. Accumulation of the simple glycosphingolipid glucosylceramide results in life-threatening lipid storage-diseases or in male infertility. How glucosylceramide regulates cellular processes...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Raju, Diana, Schonauer, Sophie, Hamzeh, Hussein, Flynn, Kevin C., Bradke, Frank, vom Dorp, Katharina, Dörmann, Peter, Yildiz, Yildiz, Trötschel, Christian, Poetsch, Ansgar, Breiden, Bernadette, Sandhoff, Konrad, Körschen, Heinz G., Wachten, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372435/
https://ncbi.nlm.nih.gov/pubmed/25803043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005063
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