The Non-lysosomal β-Glucosidase GBA2 Is a Non-integral Membrane-associated Protein at the Endoplasmic Reticulum (ER) and Golgi

GBA1 and GBA2 are both β-glucosidases, which cleave glucosylceramide (GlcCer) to glucose and ceramide. GlcCer is a main precursor for higher order glycosphingolipids but might also serve as intracellular messenger. Mutations in the lysosomal GBA1 underlie Gaucher disease, the most common lysosomal s...

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Main Authors: Körschen, Heinz G., Yildiz, Yildiz, Raju, Diana Nancy, Schonauer, Sophie, Bönigk, Wolfgang, Jansen, Vera, Kremmer, Elisabeth, Kaupp, U. Benjamin, Wachten, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561557/
https://ncbi.nlm.nih.gov/pubmed/23250757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414714
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