Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

BACKGROUND: Aggregation of the α-Synuclein (α-Syn) protein, amyloid fibril formation and progressive neurodegeneration are the neuropathological hallmarks of Parkinson's Disease (PD). However, a detailed mechanism of α-Syn aggregation/fibrillogenesis and the exact nature of toxic oligomeric spe...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Roostaee, Alireza, Beaudoin, Simon, Staskevicius, Antanas, Roucou, Xavier
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764494/
https://ncbi.nlm.nih.gov/pubmed/23339399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-5
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki