Endosulfine-alpha inhibits membrane-induced α-synuclein aggregation and protects against α-synuclein neurotoxicity

Neuropathological and genetic findings suggest that the presynaptic protein α-synuclein (aSyn) is involved in the pathogenesis of synucleinopathy disorders, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy. Evidence suggests that the self-assembly of aS...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Ysselstein, Daniel, Dehay, Benjamin, Costantino, Isabel M., McCabe, George P., Frosch, Matthew P., George, Julia M., Bezard, Erwan, Rochet, Jean-Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223451/
https://ncbi.nlm.nih.gov/pubmed/28069058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0403-7
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