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Aggregation of cellular prion protein is initiated by proximity-induced dimerization

Prion diseases or transmissible spongiform encephalopathies (TSEs) are infectious and fatal neurodegenerative disorders in humans and animals. Pathological features of TSEs include the conversion of cellular prion protein (PrP(C)) into an altered disease-associated conformation generally designated...

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Detalhes bibliográficos
Main Authors: Goggin, Kevin, Bissonnette, Cyntia, Grenier, Catherine, Volkov, Leonid, Roucou, Xavier
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954962/
https://ncbi.nlm.nih.gov/pubmed/17663754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2007.04611.x
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