Aggregation and neurotoxicity of recombinant α-synuclein aggregates initiated by dimerization

BACKGROUND: Aggregation of the α-Synuclein (α-Syn) protein, amyloid fibril formation and progressive neurodegeneration are the neuropathological hallmarks of Parkinson's Disease (PD). However, a detailed mechanism of α-Syn aggregation/fibrillogenesis and the exact nature of toxic oligomeric spe...

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Bibliografiset tiedot
Päätekijät: Roostaee, Alireza, Beaudoin, Simon, Staskevicius, Antanas, Roucou, Xavier
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2013
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764494/
https://ncbi.nlm.nih.gov/pubmed/23339399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-8-5
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