Stochastic Loss of Silencing of the Imprinted Ndn/NDN Allele, in a Mouse Model and Humans with Prader-Willi Syndrome, Has Functional Consequences

Genomic imprinting is a process that causes genes to be expressed from one allele only according to parental origin, the other allele being silent. Diseases can arise when the normally active alleles are not expressed. In this context, low level of expression of the normally silent alleles has been...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Rieusset, Anne, Schaller, Fabienne, Unmehopa, Unga, Matarazzo, Valery, Watrin, Françoise, Linke, Matthias, Georges, Beatrice, Bischof, Jocelyn, Dijkstra, Femke, Bloemsma, Monique, Corby, Severine, Michel, François J., Wevrick, Rachel, Zechner, Ulrich, Swaab, Dick, Dudley, Keith, Bezin, Laurent, Muscatelli, Françoise
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764186/
https://ncbi.nlm.nih.gov/pubmed/24039599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003752
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