Stochastic Loss of Silencing of the Imprinted Ndn/NDN Allele, in a Mouse Model and Humans with Prader-Willi Syndrome, Has Functional Consequences

Genomic imprinting is a process that causes genes to be expressed from one allele only according to parental origin, the other allele being silent. Diseases can arise when the normally active alleles are not expressed. In this context, low level of expression of the normally silent alleles has been...

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Hlavní autoři: Rieusset, Anne, Schaller, Fabienne, Unmehopa, Unga, Matarazzo, Valery, Watrin, Françoise, Linke, Matthias, Georges, Beatrice, Bischof, Jocelyn, Dijkstra, Femke, Bloemsma, Monique, Corby, Severine, Michel, François J., Wevrick, Rachel, Zechner, Ulrich, Swaab, Dick, Dudley, Keith, Bezin, Laurent, Muscatelli, Françoise
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764186/
https://ncbi.nlm.nih.gov/pubmed/24039599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003752
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