Cdk5 Inhibitory Peptide (CIP) Inhibits Cdk5/p25 Activity Induced by High Glucose in Pancreatic Beta Cells and Recovers Insulin Secretion from p25 Damage

Cdk5/p25 hyperactivity has been demonstrated to lead to neuron apoptosis and degenerations. Chronic exposure to high glucose (HG) results in hyperactivity of Cdk5 and reduced insulin secretion. Here, we set out to determine whether abnormal upregulation of Cdk5/p25 activity may be induced in a pancr...

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Détails bibliographiques
Auteurs principaux: Zheng, Ya-Li, Li, Congyu, Hu, Ya-Fang, Cao, Li, Wang, Hui, Li, Bo, Lu, Xiao-Hua, Bao, Li, Luo, Hong-Yan, Shukla, Varsha, Amin, Niranjana D., Pant, Harish C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764143/
https://ncbi.nlm.nih.gov/pubmed/24039692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063332
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