Cdk5 Inhibitory Peptide (CIP) Inhibits Cdk5/p25 Activity Induced by High Glucose in Pancreatic Beta Cells and Recovers Insulin Secretion from p25 Damage

Cdk5/p25 hyperactivity has been demonstrated to lead to neuron apoptosis and degenerations. Chronic exposure to high glucose (HG) results in hyperactivity of Cdk5 and reduced insulin secretion. Here, we set out to determine whether abnormal upregulation of Cdk5/p25 activity may be induced in a pancr...

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Detalhes bibliográficos
Main Authors: Zheng, Ya-Li, Li, Congyu, Hu, Ya-Fang, Cao, Li, Wang, Hui, Li, Bo, Lu, Xiao-Hua, Bao, Li, Luo, Hong-Yan, Shukla, Varsha, Amin, Niranjana D., Pant, Harish C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764143/
https://ncbi.nlm.nih.gov/pubmed/24039692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063332
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