TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

Chain-terminating nucleoside analogs (CTNAs) that cause stalling or premature termination of DNA replication forks are widely used as anticancer and antiviral drugs. However, it is not well understood how cells repair the DNA damage induced by these drugs. Here, we reveal the importance of tyrosyl–D...

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Sonraí Bibleagrafaíochta
Main Authors: Huang, Shar-yin N., Murai, Junko, Dalla Rosa, Ilaria, Dexheimer, Thomas S., Naumova, Alena, Gmeiner, William H., Pommier, Yves
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2013
Ábhair:
Nucleic Acid Enzymes
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763526/
https://ncbi.nlm.nih.gov/pubmed/23775789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt483
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