Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis

Aurora B kinase is an integral regulator of cytokinesis, as it stabilizes the intercellular canal within the midbody to ensure proper chromosomal segregation during cell division. Here we identified that the ubiquitin E3 ligase complex SCF(FBXL2) mediates Aurora B ubiquitination and degradation with...

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Détails bibliographiques
Auteurs principaux: Chen, B B, Glasser, J R, Coon, T A, Mallampalli, R K
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3763433/
https://ncbi.nlm.nih.gov/pubmed/23928698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.271
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