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Differential Blocking Effects of the Acetaldehyde-derived DNA Lesion N(2)-Ethyl-2′-deoxyguanosine on Transcription by Multisubunit and Single Subunit RNA Polymerases
Acetaldehyde, the first metabolite of ethanol, reacts with DNA to form adducts, including N(2)-ethyl-2′-deoxyguanosine (N(2)-Et-dG). Although the effects of N(2)-Et-dG on DNA polymerases have been well studied, nothing is known about possible effects of this lesion on transcription by RNA polymerase...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3762520/ https://ncbi.nlm.nih.gov/pubmed/18669632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804086200 |
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