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Huntingtin Acts Non Cell-Autonomously on Hippocampal Neurogenesis and Controls Anxiety-Related Behaviors in Adult Mouse

Huntington’s disease (HD) is a fatal neurodegenerative disease, characterized by motor defects and psychiatric symptoms, including mood disorders such as anxiety and depression. HD is caused by an abnormal polyglutamine (polyQ) expansion in the huntingtin (HTT) protein. The development and analysis...

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Detalhes bibliográficos
Main Authors: Pla, Patrick, Orvoen, Sophie, Benstaali, Caroline, Dodier, Sophie, Gardier, Alain M., David, Denis J., Humbert, Sandrine, Saudou, Frédéric
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760801/
https://ncbi.nlm.nih.gov/pubmed/24019939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0073902
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