Huntingtin Mediates Anxiety/Depression-Related Behaviors and Hippocampal Neurogenesis

Huntington disease (HD) is associated with early psychiatric symptoms including anxiety and depression. Here, we demonstrate that wild-type huntingtin, the protein mutated in HD, modulates anxiety/depression-related behaviors according to its phosphorylation at serines 1181 and 1201. Genetic phospho...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ben M'Barek, Karim, Pla, Patrick, Orvoen, Sophie, Benstaali, Caroline, Godin, Juliette D., Gardier, Alain M., Saudou, Frédéric, David, Denis J., Humbert, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618836/
https://ncbi.nlm.nih.gov/pubmed/23678106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5110-12.2013
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