Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation

Mouse p202 containing two HIN domains antagonizes AIM2 inflammasome signaling and potentially modifies lupus susceptibility. We found only HIN1 of p202 binds dsDNA, while HIN2 forms a homo-tetramer. Crystal structures of HIN1 revealed that dsDNA is bound on the opposite face to the site used in AIM2...

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Main Authors: Yin, Qian, Sester, David P., Tian, Yuan, Hsiao, Yu-Shan, Lu, Alvin, Cridland, Jasmyn A., Sagulenko, Vitaliya, Thygesen, Sara J., Choubey, Divaker, Hornung, Veit, Walz, Thomas, Stacey, Katryn J., Wu, Hao
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3760141/
https://ncbi.nlm.nih.gov/pubmed/23850291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.06.024
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